One look is all it takes for Sosuke Ohba (Osamu Mukai) to know a person's lifestyle, personality, upbringing, and job. With this superhuman talent, he finds the perfect match. Because he brings people together, he is known as "Mr. Love Chemistry." People who yearn to get married gather around Sosuke, day in and day out.

Shion Kohinata (Saki Aibu) is a 30 year-old woman who believes that marriage is all about getting favorable conditions. She constantly butts heads with Sosuke, but he convinces her to ditch her beliefs on the conditions of marriage. They work together at the Marriage Hunting Business Department of the event company that Himuro (Jun Kaname) runs. They were supposed to continue having "Mr. Love Chemistry" marriage hunting events, but Sosuke, without whom these events would not be possible, has been prioritizing his farming and neglecting his work with Shion. Sure enough, the Marriage Hunting Business Department becomes a useless section and its reputation plummets.

All of a sudden, a young elite named Wataru is headhunted into the company. He brought a matchmaking SNS company to success in the US. Fluent in English and highly capable at work, he is seen by many to be a great catch. Wataru has a cheerful personality, is touchy-feely, and pays a lot of lip service, but he is a bit too overwhelming for Shion.

Sosuke is an awkward fellow who can't seem to kiss the girl he likes or say "I like you." His childhood buddy Shindo (Sho Aoyagi) even had to teach him how to corner a girl against a wall. Shion is confused and constantly thinks, "Are we in a relationship?" Despite this ambiguity, they decide to live together in Shion's apartment while they prepare to launch their business.

One of the attractions of this drama is Mariko Oshima (Ryo), a beautiful but extremely needy woman who finds that all the men she dates end up running the other way! She is the type of woman who keeps sending her text message if she doesn't get a reply. Mariko is the embodiment of a woman who is destined to fail in relationships. Will Sosuke and Shion be able to show such a high-maintenance woman the path to happiness?

What does it mean to "love" and "be in a relationship?" Is there a shortcut to "happiness?""Mr. Love Chemistry," who is considered to be the god of marriage, and four women in their 20s to 60s (Mayu Matsuoka, Saki Aibu, Ryo, and Mitsuko Baisho), come together to share their views on love and marriage while searching for answers to these questions.